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师资

马大为
讲席教授
中国科学院院士
madw@sustech.edu.cn

马大为,讲席教授,中国科学院院士。

1984年毕业于山东大学化学系,1989年于中国科学院上海有机化学研究所获博士学位。1990-1994年在美国匹兹堡大学化学系和Mayo Clinic神经化学和神经生物学研究部进行博士后研究。1994年回到中国科学院上海有机化学研究所工作,2019年当选中国科学院院士。现任美国化学会Journal of Organic Chemistry 副主编,Acc. Chem. Res., Nat. Prod. Rep., Adv. Syn. Catal.,Chem. Asia J., Tetrahedron/Tetrahedron Letters 等国际杂志的顾问编委等职务。

研究方向为化金沙赌玚登录物学导向的有机合成,药物化学。已发表论文300余篇。他发展的偶联反应曾被上千次用于生物活性小分子的创制以及3个药物的工业化生产,发展的抗肿瘤药物曲贝替定的高效合成路线也已进入工业化生产,最近发现的两个激酶抑制剂分别作为治疗神经退行性疾病和肺癌的药物,在欧洲和中国进入了一期临床实验研究。


最近获得的奖励包括ACS Cope scholar award (2018) , 未来科学大奖之“物质科学奖”(2018) ,中国科学院杰出科技成就奖(2019)等。


代表性论文:

 

1. Total Synthesis of Leucosceptroids A and B, Sheng Guo, Jie Liu, Dawei Ma, Angew. Chem. Int. Ed. 2015, 54, 1298.

 

2. Intramolecular dearomative oxidative coupling of indoles: A unified strategy for the total synthesis of indoline alkaloid, Weiwei Zi, Zhiwei Zuo, Dawei Ma, Acc. Chem. Res. 2015, 48, 702.

 

3. CuI/Oxalic Diamides Catalyzed Coupling Reaction of (Hetero)Aryl Chlorides and Amines, Wei Zhou, Mengyang Fan, Junli Yin, Yongwen Jiang, Dawei Ma, J. Am. Chem. Soc. 2015, 137, 11942.

 

4. Rhodium-Catalyzed Regioselective C7-Functionalization of N-Pivaloyl Indoles, Lanting Xu, Chao Zhang, Yupeng He, Lushi Tan, Dawei Ma, Angew. Chem. Int. Ed. 2016, 55, 321.

 

5. Diaryl Ether Formation through CuI/Oxalic Diamide Catalyzed Coupling of (Hetero)aryl Chlorides and Phenols, Mengyang Fan, Wei Zhou, Yongwen Jiang, Dawei Ma, Angew. Chem. Int. Ed. 2016, 55, 6211.

 

6. Copper-Catalyzed Hydroxylation of (Hetero)aryl Halides under Mild Conditions, Shanghua Xia, Lu Gan, Kailiang Wang, Zheng Li, Dawei Ma, J. Am. Chem. Soc. 2016, 138, 13492.

 

7. Convergent route to ent-Kaurane diterpenoids: Total synthesis of Lungshengenin D and 1a,6a-Diacetoxy-ent-kaura-9(11),16-dien-12,15-dione. Xiangbo Zhao, Wu Li, Junjie Wang, Dawei Ma*, J. Am. Chem. Soc., 2017, 139, 2932-2935.

 

8. Selected copper-based reactions for C-N, C-O, C-S and C-C bond formation. Subhajit Bhunia, Govind Goroba Pawar, S. Vijay Kumar, Yongwen Jiang, Dawei Ma*, Angew. Chem. Int. Ed., 2017, 56, 16136-16179.

 

9. Divergent entry to gelsedine-type alkaloids: total syntheses of (-)-Gelsedilam, (-)-Gelsenicine, (-)-Gelsedine, and (-)-Gelsemoxonine. Pingluan Wang, Yang Gao, Dawei Ma*, J. Am. Chem. Soc., 2018, 140, 11608-11612.

 

10. Thiourea-catalyzed asymmetric michael addition of carbazolones to 2-chloroacrylonitrile: total synthesis of 5,22-Dioxokopsane, Kopsinidine C, and Demethoxycarbonylkopsin. Dongshun Ni, Yi Wei, Dawei Ma*, Angew. Chem. Int. Ed., 2018, 57, 10207 -10211.

 

11. A unified approach for the assembly of atisine- and hetidine-type diterpenoid alkaloids: total syntheses of azitine and the proposed structure of Navirine C. Jie Liu, Dawei Ma*, Angew. Chem. Int. Ed., 2018, 57, 6676 -6680.

 

12. Oxalic Diamides and tert-Butoxide: Two Types of Ligands Enabling Practical Access to Alkyl Aryl Ethers via Cu-Catalyzed Coupling Reaction, Zhixiang Chen, Yongwen Jiang, Li Zhang, Yinlong Guo, Dawei Ma*, J. Am. Chem. Soc. 2019, 141, 3541–3549.

 

13. A Scalable Total Synthesis of the Antitumor Agents Et-743 and Lurbinectedin, Weiming He, Zhigao Zhang, Dawei Ma*, Angew. Chem. Int. Ed. 2019, 58, 3972-3976.

 

14. Total Synthesis of Kopsinitarine E, Karre Nagaraju, Dongshun Ni, Dawei Ma, Angew. Chem. Int. Ed. 2020, 59, 22039-22042.

 

15. In Pursuit of Synthetic Efficiency: Convergent Approaches, Yang Gao, Dawei Ma, Acc. Chem. Res. 2021, 54, 569-582.

 

16. Assembly of a-(Hetero)aryl Nitriles via Copper-Catalyzed Coupling Reactions with (Hetero)aryl Chlorides and Bromides, Chen, Y.; Xu, L.; Jiang, Y.; Ma, D. Angew. Chem. Int. Ed. 2021, 60, 7082-7086